The N-end rule: Functions, mysteries, uses

被引：702

作者：

Varshavsky, A

机构：

[1] Division of Biology, California Institute of Technology, Pasadena

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 22期

关键词：

ubiquitin; proteolysis; N-degron; peptide import; apoptosis;

D O I：

10.1073/pnas.93.22.12142

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.

引用

页码：12142 / 12149

页数：8

共 79 条

[1] An Escherichia coli chromosomal ''addiction module'' regulated by 3',5'-bispyrophosphate: A model for programmed bacterial cell death
Aizenman, E
EngelbergKulka, H
Glaser, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) : 6059 - 6063
[2] A RECOGNITION COMPONENT OF THE UBIQUITIN SYSTEM IS REQUIRED FOR PEPTIDE-TRANSPORT IN SACCHAROMYCES-CEREVISIAE
ALAGRAMAM, K
NAIDER, F
BECKER, JM
[J]. MOLECULAR MICROBIOLOGY, 1995, 15 (02) : 225 - 234
[3] COTRANSLATIONAL PROCESSING AND PROTEIN-TURNOVER IN EUKARYOTIC CELLS
ARFIN, SM
BRADSHAW, RA
[J]. BIOCHEMISTRY, 1988, 27 (21) : 7979 - 7984
[4] STRESS RESISTANCE IN SACCHAROMYCES-CEREVISIAE IS STRONGLY CORRELATED WITH ASSEMBLY OF A NOVEL TYPE OF MULTIUBIQUITIN CHAIN
ARNASON, T
ELLISON, MJ
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) : 7876 - 7883
[5] BABOSHINA OV, 1996, J BIOL CHEM, V271, P2832
[6] THE DEGRADATION SIGNAL IN A SHORT-LIVED PROTEIN
BACHMAIR, A
VARSHAVSKY, A
[J]. CELL, 1989, 56 (06) : 1019 - 1032
[7] INVIVO HALF-LIFE OF A PROTEIN IS A FUNCTION OF ITS AMINO-TERMINAL RESIDUE
BACHMAIR, A
FINLEY, D
VARSHAVSKY, A
[J]. SCIENCE, 1986, 234 (4773) : 179 - 186
[8] YEAST N-TERMINAL AMIDASE - A NEW ENZYME AND COMPONENT OF THE N-END RULE PATHWAY
BAKER, RT
VARSHAVSKY, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (20) : 12065 - 12074
[9] INHIBITION OF THE N-END RULE PATHWAY IN LIVING CELLS
BAKER, RT
VARSHAVSKY, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1090 - 1094
[10] BALZI E, 1990, J BIOL CHEM, V265, P7464

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