Which molecular targets are most relevant to general anaesthesia?

被引：115

作者：

Franks, NP ^{[1
]}

Lieb, WR ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Blackett Lab, Biophys Sect, London SW7 2BZ, England

来源：

TOXICOLOGY LETTERS | 1998年 / 101卷

关键词：

anaesthetic concentrations; GABA(A) receptors; ligand-gated channels; optical isomers; stereoselectivity;

D O I：

10.1016/S0378-4274(98)00158-1

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1. In view of the large number of possible molecular targets of general anaesthetics, it is necessary to have some criteria for judging which targets are important for producing general anaesthesia and which are probably not. 2. We consider in detail two criteria: sensitivity to clinically relevant concentrations of anaesthetics and stereoselectivity to anaesthetic optical isomers. 3. The targets which currently emerge as most important belong to an anaesthetic-sensitive superfamily of genetically related fast neurotransmitter-gated receptor channels present at central synapses. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 8

页数：8

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