Genome-wide ENU mutagenesis to reveal immune regulators

被引：105

作者：

Nelms, KA ^{[1
]}

Goodnow, CC ^{[1
]}

机构：

[1] John Curtin Sch Med Res, Med Genome Ctr, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia

来源：

IMMUNITY | 2001年 / 15卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(01)00199-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A complete list of molecular components for immune system function is now available with the completion of the human and mouse genome sequences. However, identification and functional annotation of genes involved in immunological processes require a discovery methodology that can efficiently and broadly analyze the complex interplay of these components in vivo. Our recent experience indicates that genome-wide chemical mutagenesis in the mouse is an extremely powerful methodology for the identification of genes required for complex immunological processes.

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页码：409 / 418

页数：10

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