The expanding universe of inflammatory bowel disease genetics

被引：27

作者：

Achkar, Jean-Paul ^{[1
]}

Duerr, Richard ^{[2
,3
]}

机构：

[1] Cleveland Clin, Ctr Inflammatory Bowel Dis, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA

[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Med, Div Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA

[3] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA

来源：

CURRENT OPINION IN GASTROENTEROLOGY | 2008年 / 24卷 / 04期

关键词：

ATG16L1; Crohn's disease; genetics; IL23R; NOD2;

D O I：

10.1097/MOG.0b013e3283009c92

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purpose of review Genetic factors play an important role in the pathogenesis of inflammatory bowel disease. In this review, we will provide an update on the rapid advances in the discovery of inflammatory bowel disease, primarily Crohn's disease, associated genes. Recent findings Seven recently published Crohn's disease genome-wide association studies have confirmed prior findings related to the nucleotide-binding oligomerization domain 2 (NOD2) gene and the IBD5 locus. In addition, 10 novel loci have been identified and well replicated. Summary Several promising associations between Crohn's disease and gene variants have been identified and replicated, the two most widely replicated being variants in the IL23R and ATG16L1 genes. These findings highlight and further support the importance of the immune system and its interactions with the intestinal microflora in the pathogenesis of inflammatory bowel disease.

引用

页码：429 / 434

页数：6

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