Stem cell therapy for chronic lung diseases: Hope and reality

被引：17

作者：

Agostini, Carlo ^{[1
]}

机构：

[1] Univ Padua, Sch Med, Dept Clin & Expt Med, I-35128 Padua, Italy

来源：

RESPIRATORY MEDICINE | 2010年 / 104卷

关键词：

Chronic lung disease; Stem cell transplantation; Haematopoietic stem cells; Embryonic stem cells; ENDOTHELIAL PROGENITOR CELLS; MARROW-DERIVED CELLS; PULMONARY-HYPERTENSION; EPITHELIAL-CELLS; CYSTIC-FIBROSIS; IN-VIVO; TRANSPLANTATION; DIFFERENTIATION; DERIVATION; CHIMERISM;

D O I：

10.1016/j.rmed.2010.03.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A number of recently published results have suggested the possibility of using stem cells to regenerate lung tissue. Several groups have developed various animal models employing haematopoietic stem cells, mesenchymal and endothelial progenitors, and embryonic cells, in which it has been possible to ameliorate the diseased lung. Despite these stimulating in vivo results a number of questions are pending before stem cell derivatives can be used in human lung disorders. This brief review will examine encouraging data that suggest the possibility of using stem cells in the therapy of lung diseases. In parallel, controversial findings are reviewed indicating that caution should be recommended before proposing to utilize stem cells in human lung diseases. (C) 2010 Elsevier Ltd. All rights reserved.

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收藏

页码：S86 / S91

页数：6

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