Clinical potential of mannose-binding lectin-replacement therapy

被引:38
作者
Summerfield, JA [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Div Med, Fac Med, London W2 1NY, England
关键词
cystic fibrosis; immunodeficiency; infection; mannan-binding lectin (MBL); rheumatoid arthritis; therapy;
D O I
10.1042/BST0310770
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mannose-binding lectin (MBL; also known as mannan-binding lectin) is an important component of innate immunity. MBL levels are mainly genetically determined. Low serum MBL levels and their cognate haplotypes have been associated with a wide range of infections. However, most subjects with MBL deficiency remain healthy. MBL deficiency is also associated with non-infectious diseases including systemic lupus erythematosus, rheumatoid arthritis, cystic fibrosis and common variable immunodeficiency. MBL deficiency may affect susceptibility to (e.g. meningococcal disease), or alter the natural history of (e.g. rheumatoid arthritis, cystic fibrosis), a disease. MBL (plasma-derived or recombinant) therapy has yet to be shown to be safe and effective. Potentially it may be useful in MBL-deficient patients to reduce susceptibility to, or enhance recovery from, bacterial infection or to alter the natural history of a disease (disease-modifying drug). in practise the place of MBL therapy may be as a disease-modifying drug to reduce the severity of rheumatoid arthritis and to preserve lung and liver function in cystic fibrosis. MBL therapy may also ameliorate various immunodeficiency syndromes. A potential hazard of MBL therapy is enhanced complement-mediated host damage. The place of MBL therapy will await results of randomized controlled clinical trials.
引用
收藏
页码:770 / 773
页数:4
相关论文
共 34 条
  • [1] Association of familial deficiency of mannose-binding lectin and meningococcal disease
    Bax, WA
    Cluysenaer, OJJ
    Bartelink, AKM
    Aerts, PC
    Ezekowitz, RAB
    van Dijk, H
    [J]. LANCET, 1999, 354 (9184) : 1094 - 1095
  • [2] Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans
    Bellamy, R
    Ruwende, C
    McAdam, KPWJ
    Thursz, M
    Sumiya, M
    Summerfield, J
    Gilbert, SC
    Corrah, T
    Kwiatkowski, D
    Whittle, HC
    Hill, AVS
    [J]. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 1998, 91 (01) : 13 - 18
  • [3] Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease
    Foster, CB
    Lehrnbecher, T
    Mol, F
    Steinberg, SM
    Venzon, DJ
    Walsh, TJ
    Noack, D
    Rae, J
    Winkelstein, JA
    Curnutte, JT
    Chanock, SJ
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (12) : 2146 - 2155
  • [4] Association of variant alleles of mannose binding lectin with severity of pulmonary disease in cystic fibrosis: cohort study
    Gabolde, M
    Guilloud-Bataille, M
    Feingold, J
    Besmond, C
    [J]. BRITISH MEDICAL JOURNAL, 1999, 319 (7218) : 1166 - 1167
  • [5] The mannose binding lectin gene influences the severity of chronic liver disease in cystic fibrosis
    Gabolde, M
    Hubert, D
    Guilloud-Bataille, M
    Lenaerts, C
    Feingold, J
    Besmond, C
    [J]. JOURNAL OF MEDICAL GENETICS, 2001, 38 (05) : 310 - 311
  • [6] Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin
    Garred, P
    Madsen, HO
    Balslev, U
    Hofmann, B
    Pedersen, C
    Gerstoft, J
    Svejgaard, A
    [J]. LANCET, 1997, 349 (9047) : 236 - 240
  • [7] Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis
    Garred, P
    Pressler, T
    Madsen, HO
    Frederiksen, B
    Svejgaard, A
    Hoiby, N
    Schwartz, M
    Koch, C
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (04) : 431 - 437
  • [8] Mannose-binding lectin (MBL) therapy in an MBL-deficient patient with severe cystic fibrosis lung disease
    Garred, P
    Pressler, T
    Lanng, S
    Madsen, HO
    Moser, C
    Laursen, I
    Balstrup, F
    Koch, C
    Koch, C
    [J]. PEDIATRIC PULMONOLOGY, 2002, 33 (03) : 201 - 207
  • [9] INCREASED FREQUENCY OF HOMOZYGOSITY OF ABNORMAL MANNAN-BINDING-PROTEIN ALLELES IN PATIENTS WITH SUSPECTED IMMUNODEFICIENCY
    GARRED, P
    MADSEN, HO
    HOFMANN, B
    SVEJGAARD, A
    [J]. LANCET, 1995, 346 (8980): : 941 - 943
  • [10] Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease
    Hibberd, ML
    Sumiya, M
    Summerfield, JA
    Booy, R
    Levin, M
    [J]. LANCET, 1999, 353 (9158) : 1049 - 1053