AMP-activated protein kinase and its downstream transcriptional pathways

被引:348
作者
Canto, Carles [1 ]
Auwerx, Johan [1 ]
机构
[1] Ecole Polytech Fed Lausanne, Lab Integrat & Syst Physiol, SV IBI, CH-1015 Lausanne, Switzerland
基金
欧洲研究理事会; 瑞士国家科学基金会;
关键词
AMPK; Energy metabolism; PGC-1; alpha; SIRT1; ACETYL-COA CARBOXYLASE; HUMAN SKELETAL-MUSCLE; SMALL-MOLECULE ACTIVATORS; CREB COACTIVATOR TORC2; ELITE DISTANCE RUNNERS; FATTY-ACID OXIDATION; MITOCHONDRIAL BIOGENESIS; GLUCOSE-HOMEOSTASIS; HISTONE DEACETYLASE; CATALYTIC SUBUNIT;
D O I
10.1007/s00018-010-0454-z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic processes. Its properties as an energy sensor allow it to couple the energy status of the cell to the metabolic environment. These adaptations not only take place through the acute modulation of key metabolic enzymes via direct phosphorylation, but also through a slower transcriptional adaptative response. The question of how AMPK regulates the expression of a number of gene sets, such as those related to mitochondrial biogenesis, energy production and oxidative protection, is only beginning to be elucidated, and still many questions remain to be answered. In this review we will try to integrate our current knowledge on how AMPK regulates transcription in muscle and liver, which will serve as examples to illustrate the major advances in the field and the key challenges ahead.
引用
收藏
页码:3407 / 3423
页数:17
相关论文
共 181 条
  • [1] Real-time imaging of peroxisome proliferator-activated receptor-γ coactivator-1α promoter activity in skeletal muscles of living mice
    Akimoto, T
    Sorg, BS
    Yan, Z
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2004, 287 (03): : C790 - C796
  • [2] MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways
    Al-Khalili, L
    Chibalin, AV
    Yu, M
    Sjödin, B
    Nylén, C
    Zierath, JR
    Krook, A
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2004, 286 (06): : C1410 - C1416
  • [3] LKB1-dependent signaling pathways
    Alessi, Dario R.
    Sakamoto, Kei
    Bayascas, Jose R.
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 : 137 - 163
  • [4] SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD
    Amat, Ramon
    Planavila, Anna
    Chen, Shen Liang
    Iglesias, Roser
    Giralt, Marta
    Villarroya, Francesc
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (33) : 21872 - 21880
  • [5] Liver adenosine monophosphate-activated kinase-α2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
    Andreelli, F
    Foretz, M
    Knauf, C
    Cani, PD
    Perrin, C
    Iglesias, MA
    Pillot, B
    Bado, A
    Tronche, F
    Mithieux, G
    Vaulont, S
    Burcelin, R
    Viollet, B
    [J]. ENDOCRINOLOGY, 2006, 147 (05) : 2432 - 2441
  • [6] Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
    Baar, K
    Wende, AR
    Jones, TE
    Marison, M
    Nolte, LA
    Chen, M
    Kelly, DP
    Holloszy, JO
    [J]. FASEB JOURNAL, 2002, 16 (14) : 1879 - 1886
  • [7] SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice
    Banks, Alexander S.
    Kon, Ning
    Knight, Colette
    Matsumoto, Michihiro
    Gutierrez-Juarez, Roger
    Rossetti, Luciano
    Gu, Wei
    Accili, Domenico
    [J]. CELL METABOLISM, 2008, 8 (04) : 333 - 341
  • [8] Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation
    Barre, Laura
    Richardson, Christine
    Hirshman, Michael F.
    Brozinick, Joseph
    Fiering, Steven
    Kemp, Bruce E.
    Goodyear, Laurie J.
    Witters, Lee A.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 292 (03): : E802 - E811
  • [9] Resveratrol improves health and survival of mice on a high-calorie diet
    Baur, Joseph A.
    Pearson, Kevin J.
    Price, Nathan L.
    Jamieson, Hamish A.
    Lerin, Carles
    Kalra, Avash
    Prabhu, Vinayakumar V.
    Allard, Joanne S.
    Lopez-Lluch, Guillermo
    Lewis, Kaitlyn
    Pistell, Paul J.
    Poosala, Suresh
    Becker, Kevin G.
    Boss, Olivier
    Gwinn, Dana
    Wang, Mingyi
    Ramaswamy, Sharan
    Fishbein, Kenneth W.
    Spencer, Richard G.
    Lakatta, Edward G.
    Le Couteur, David
    Shaw, Reuben J.
    Navas, Placido
    Puigserver, Pere
    Ingram, Donald K.
    de Cabo, Rafael
    Sinclair, David A.
    [J]. NATURE, 2006, 444 (7117) : 337 - 342
  • [10] 5′-AMP-activated protein kinase signaling in Caenorhabditis elegans
    Beale, Elmus G.
    [J]. EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 233 (01) : 12 - 20