Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro

被引：440

作者：

Kaser, S ^{[1
]}

Kaser, A ^{[1
]}

Sandhofer, A ^{[1
]}

Ebenbichler, CF ^{[1
]}

Tilg, H ^{[1
]}

Patsch, JR ^{[1
]}

机构：

[1] Univ Innsbruck Hosp, Dept Med, Div Gastroenterol, A-6020 Innsbruck, Austria

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 309卷 / 02期

关键词：

resistin; insulin resistance; inflammation; in vitro; PBMC;

D O I：

10.1016/j.bbrc.2003.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resistin is a recently discovered polypeptide that induces insulin resistance in rodents. While in rodents resistin is predominantly expressed in adipocytes, in humans peripheral blood mononuclear cells (PBMC) seem to a be a major source of resistin. In the present study, we show that in human PBMC resistin mRNA expression-determined by fluorescence-based real-time polymerase chain reaction-is strongly increased by the proinflammatory cytokines interleukin (IL)-1, IL-6, tumor necrosis factor alpha (TNF-alpha), and also by lipopolysaccharides (LPS), respectively, while no effect was found by interferon-gamma (IFN-gamma) or leptin. Our results suggest that in humans resistin may be a link in the well-known association between inflammation and insulin resistance. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：286 / 290

页数：5

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