Tramadol concentrations in blood and in cerebrospinal fluid in a neonate

被引：6

作者：

Allegaert, K ^{[1
]}

de Hoon, J

Verbesselt, R

Devlieger, H

Tibboel, D

机构：

[1] Erasmus Med Ctr, Dept Paediat Surg, Rotterdam, Netherlands

[2] Univ Hosp Gasthuisberg, Dept Paediat, B-3000 Louvain, Belgium

[3] Univ Hosp Gasthuisberg, Ctr Clin Pharmacol, B-3000 Louvain, Belgium

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 2005年 / 60卷 / 12期

关键词：

pain; neonate; tramadol; CSF pharmacokinetics; pharmacodynamics;

D O I：

10.1007/s00228-004-0872-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.

引用

页码：911 / 913

页数：3

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