Harnessing macrophage plasticity for tissue regeneration

被引：110

作者：

Smith, Tim D. ^{[1
,2
]}

Nagalla, Raji R. ^{[1
,2
]}

Chen, Esther Y. ^{[2
,3
]}

Liu, Wendy F. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA USA

[2] Univ Calif Irvine, Edwards Lifesci Ctr Adv Cardiovasc Technol, Irvine, CA USA

[3] Univ Calif Irvine, Dept Chem Engn & Mat Sci, Irvine, CA USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2017年 / 114卷

基金：

美国国家卫生研究院;

关键词：

Wound healing; Immunomodulation; Macrophage polarization; Biomaterials; Nanopartides; MESENCHYMAL STEM-CELLS; FOREIGN-BODY RESPONSE; SPINAL-CORD-INJURY; HYALURONIC-ACID; IN-VIVO; PROINFLAMMATORY CYTOKINES; ACTIVATED MACROPHAGES; BIOLOGIC SCAFFOLDS; SURFACE-TOPOGRAPHY; RECRUITMENT AGENT;

D O I：

10.1016/j.addr.2017.04.012

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Macrophages are versatile and plastic effector cells of the immune system, and contribute to diverse immune functions including pathogen or apoptotic cell removal, inflammatory activation and resolution, and tissue healing. Macrophages function as signaling regulators and amplifiers, and influencing their activity is a powerful approach for controlling inflammation or inducing a wound-healing response in regenerative medicine. This review discusses biomaterials-based approaches for altering macrophage activity, approaches for targeting drugs to macrophages, and approaches for delivering macrophages themselves as a therapeutic intervention. (C) 2017 Published by Elsevier B.V.

引用

页码：193 / 205

页数：13

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