Early feeding, antenatal glucocorticoids, and human milk decrease intestinal permeability in preterm infants

被引:116
作者
Shulman, RJ
Schanler, RJ
Lau, C
Heitkemper, M
Ou, CN
Smith, EO
机构
[1] Baylor Coll Med, Childrens Nutr Res Ctr, USDA ARS, Dept Pediat, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
[3] Texas Childrens Hosp, Houston, TX 77030 USA
[4] Univ Washington, Dept Biobehav Nursing, Seattle, WA 98195 USA
关键词
D O I
10.1203/00006450-199810000-00009
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
To determine the effects of age, feeding regimen, and antenatal glucocorticoids on intestinal permeability, preterm infants (n = 132) were stratified by gestational age and by diet (mothers' own milk versus preterm formula), and assigned randomly to one of four feeding regimens: early-continuous, early-bolus, standard-continuous, and standard-bolus. At 10, 28, and 50 d of age permeability was determined by measuring the ratio of lactulose/mannitol in the urine after the two sugars were administered enterally for 30 h. The mean (+/-SE) birth weight and gestational age of the infants were 1044 +/- 13 g and 27 +/- 0.1 wk, respectively. Permeability changed as a function of age (p = 0.003). Early feeding was associated with a reduction in perme ability at 10 d of age (p = 0.01). Antenatal steroid administration was associated with decreased permeability at 28 d of age (p = 0.017). The feeding of human milk (versus formula) was associated with decreased permeability at 28 d of age (p = 0.02). Continuous versus bolus feeding did not affect permeability.
引用
收藏
页码:519 / 523
页数:5
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