Malaria:: a peek at the var variorum

被引：5

作者：

Chookajorn, Thanat ^{[1
]}

Costanzo, Marna S. ^{[2
]}

Hartl, Daniel L. ^{[2
]}

Deitsch, Kirk W. ^{[3
]}

机构：

[1] Mahidol Univ, Fac Sci, Dept Biochem, Bangkok 10400, Thailand

[2] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA

[3] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA

来源：

TRENDS IN PARASITOLOGY | 2007年 / 23卷 / 12期

关键词：

PLASMODIUM-FALCIPARUM; VAR GENE; RECOMBINATION; DIVERSITY; PREGNANCY; TRANSCRIPTION; SEQUENCE; SURFACE; FAMILY;

D O I：

10.1016/j.pt.2007.08.022

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Geneticists encountering the diversity of the malaria parasite's var gene family for the first time often complain that its complexity is a nightmare. A new article by Barry et al. presents the latest and most systematic attempt to date to decipher the var variorum. This important work, combined with other recent articles on var global variation such as that by Kraemer et al., suggests that only the tip of the var diversity iceberg is currently in view. In this article, we discuss these recent results and provide an overview of current understanding of var diversity.

引用

页码：563 / 565

页数：3

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