Biotransformation of triptolide and triptonide by cell suspension cultures of Catharanthus roseus

被引：21

作者：

Ning, LL

Han, J

Zhang, XY

Guo, HZ

Bi, KS

Guo, DA ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China

[3] State Drug Adm, Ctr Drug Evaluat, Beijing 100038, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2004年 / 6卷 / 02期

基金：

中国国家自然科学基金;

关键词：

biotransformation; triptolide; triptonide; cell suspension cultures; Catharanthus roseus;

D O I：

10.1080/1028602031000135567

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Catharanthus roseus cell suspension cultures were used to bioconvert both triptolide (1) and triptonide (2). The same reaction path was followed in both biotransformations. Two biotransformed products were obtained and their structures identified as triptriolide (3) and 12beta,13alpha-dihydroxytriptonide (4), respectively, from 1 and 2 . Product 4 is a new compound.

引用

页码：93 / 97

页数：5

共 18 条

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[3]

Regio- and stereo-selective biotransformation of 2α,5α,10β,14β-tetra-acetoxy-4(20), 11-taxadiene by Ginkgo cell suspension cultures [J].