New submonomers for poly N-substituted glycines (peptoids)

被引：49

作者：

Uno, T ^{[1
]}

Beausoleil, E ^{[1
]}

Goldsmith, RA ^{[1
]}

Levine, BH ^{[1
]}

Zuckermann, RN ^{[1
]}

机构：

[1] Chiron Corp, Chiron Technol, Emeryville, CA 94608 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(98)02696-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five protected submonomers for peptoid synthesis were prepared, including N-in-BOC-tryptamine, O-t-butyl tyramine, PMC-guanidino-propylamine, 6-amino-6-deoxy-D-galactopyranose diacetonide, and 5-amino-2,2-dimethyl-1,3-dioxane. The first three mimic natural aminoacid sidechains i.e, tryptophan, tyrosine, and arginine, while the last two provide hydrophilic sidechains. These submonomers were successfully used for preparation of oligo-peptoids by the submonomer synthesis method. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1475 / 1478

页数：4

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