The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein

被引：30

作者：

Wiedemann, M ^{[1
]}

Trueb, B ^{[1
]}

机构：

[1] Univ Bern, ME Muller Inst, CH-3010 Bern, Switzerland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2001年 / 1520卷 / 03期

关键词：

bone development; cartilage; endochondral ossification; fibroblast growth factor; FGF receptor; gene structure; mouse;

D O I：

10.1016/S0167-4781(01)00267-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mouse Fgfrl1 gene codes for a novel cell surface protein that is closely related to the family of the FGF receptors. It contains three extracellular Ig C2 loops and an acidic box, which share 29-33% sequence identity (48-50% similarity) with FGF receptors 1-4. The intracellular portion of the novel protein, however, lacks a tyrosine kinase domain required for signal transduction by transphosphorylation. The gene for Fgfrl1 comprises six exons and is located on mouse chromosome 5 in close proximity to the Idua gene for L-iduronidase. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：247 / 250

页数：4

共 16 条

[1] Matrilin-3 from chicken cartilage [J].