Cell-autonomous and non-cell-autonomous functions of caspase-8

被引：10

作者：

Ben Moshe, Tehila ^{[1
]}

Kang, Tae-Bong ^{[1
]}

Kovalenko, Andrew ^{[1
]}

Barash, Hila ^{[2
,3
]}

Abramovitch, Rinat ^{[2
,3
]}

Galun, Eithan ^{[2
]}

Wallach, David ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

[2] Hadassah Hebrew Univ Med Ctr, Goldyne Savad Inst Gene Therapy, Jerusalem, Israel

[3] Hadassah Hebrew Univ Med Ctr, Human Biol Res Ctr, MRI MRS Lab, Jerusalem, Israel

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2008年 / 19卷 / 3-4期

关键词：

apoptosis; caspase-8; cell-autonomous; therapy; TNF;

D O I：

10.1016/j.cytogfr.2008.04.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells in vivo do not act in isolation. Therefore, when attempting to predict the results of pharmaceutical modulation of the function of a protein, we must also take into account the non-cell-autonomous consequences of such modulation. Studies of caspase-8 initially indicated that it serves as the proximal enzyme in cellular self-destruction dictated through the extrinsic cell-death pathway. Later studies revealed that it also participates in mechanisms affecting cell growth and survival. This essay presents a brief account of a study indicating that, apart from functional changes that are cell autonomous, tissue-specific deletion of caspase-8 in mice also has non-cell-autonomous effects with consequences that might even be the opposite of the cell-autonomous ones. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：209 / 217

页数：9

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