The aqueous extract of Rhodiola sachalinensis root enhances the expression of inducible nitric oxide synthase gene in RAW264.7 macrophages

被引:34
作者
Seo, WG [1 ]
Pae, HO [1 ]
Oh, GS [1 ]
Kim, NY [1 ]
Kwon, TO [1 ]
Shin, MK [1 ]
Chai, KY [1 ]
Chung, HT [1 ]
机构
[1] Wonkwang Univ, MRRC, Chonbuk 570749, South Korea
关键词
Rhodiola sachalinensis; nitric oxide; macrophages; inducible nitric oxide synthase;
D O I
10.1016/S0378-8741(01)00220-3
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In the present study, we examined the effects of the aqueous extract of Rhodiola sachalinensis root (RSE) on the expression of inducible nitric oxide (NO) synthase (iNOS) gene in RAW264.7 macrophages. RSE synergistically increased NO synthesis in interferon-gamma -primed macrophages. Reverse transcriptase polymerase chain reaction and Northern blotting analysis revealed that RSE may provide a second triggering signal for the synergistic induction of iNOS mRNA expression. Thus, iNOS-mediated NO synthesis in response to RSE may be one mechanism whereby this herbal medicine elicits its therapeutic effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:119 / 123
页数:5
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