Ventrolateral medullary control of cardiovascular activity during muscle contraction

被引:51
作者
Ally, A
机构
[1] Univ New England, Coll Osteopath Med, Dept Pharmacol, Biddeford, ME 04005 USA
[2] Univ New England, Coll Osteopath Med, Dept Biochem, Biddeford, ME 04005 USA
[3] Univ New England, Coll Osteopath Med, Dept Nutr, Biddeford, ME 04005 USA
关键词
arterial blood pressure; heart rate; sympathetic nerve activity; exercise pressor reflex; central command; rostral ventrolateral medulla; caudal ventrolateral medulla; muscle afferents; spinal cord; excitatory amino acid receptors; AMPA receptors; 5-HT receptors; alpha-adrenoceptors; opioid receptors; muscarinic-cholinergic receptors; serotonin; glutamate; cat; rat;
D O I
10.1016/S0149-7634(97)00069-9
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
An overview of the role of ventrolateral medulla (VLM) in regulation of cardiovascular activity is presented. A summary of VLM anatomy and its functional relation to other areas in the central nervous system is described. Over the past few years, various studies have investigated the VLM and its involvement in cardiovascular regulation during static muscle contraction, a type of static exercise as seen, for example, during knee extension or hand-grip exercise. Understanding the neural mechanisms that are responsible for regulation of cardiovascular activity during static muscle contraction is of particular interest since it helps understand circulatory adjustments in response to an increase in physical activity. This review surveys the role of several receptors and neurotransmitters in the VLM that are associated with changes in mean arterial pressure and heart rate during static muscle contraction in anesthetized animals. Possible mechanisms in the VLM that modulate cardiovascular changes during static muscle contraction are summarized and discussed. Localized administration of an excitatory amino-acid antagonist into the rostral portion of the VLM (RVLM) attenuates increases in blood pressure and heart rate during static muscle contraction, whereas its administration into the caudal part of the VLM (CVLM) augments these responses. Opioid or 5-HT1A receptor stimulation in the RVLM, but not in the CVLM, attenuates cardiovascular responses to muscle contraction. Furthermore, intravenous, intracerebroventricular or intracisternal injection of an alpha(2)-adrenoceptor agonist or a cholinesterase inhibitor attenuates increases in blood pressure and heart rate during static muscle contraction. Finally, the possible involvement of endogenous neurotransmitters in the RVLM and the CVLM associated with cardiovascular responses during static muscle contraction is discussed. An overview of the role of the VLM in the overall cardiovascular control network in the brain is presented and critically reviewed. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
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页码:65 / 86
页数:22
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