New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus

被引：45

作者：

Liu, YH ^{[1
]}

Mansoor, TA ^{[1
]}

Hong, JK ^{[1
]}

Lee, CO ^{[1
]}

Sim, CJ ^{[1
]}

Im, KS ^{[1
]}

Kim, ND ^{[1
]}

Jung, JH ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 11期

关键词：

D O I：

10.1021/np030268e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

New norsesterterpenoids (3 and 4), a sesterterpenoid (6), pyrroloterpenoids (7-10), and a stereoisomer of kurospongin (5) were isolated, along with known furanosesterterpenes (11-15), from two marine sponges of the genus Sarcotragus. The gross structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of NMR and CD spectroscopy. The compounds were evaluated for cytotoxicity against five human tumor cell lines and were found to exhibit marginal to moderate activity.

引用

页码：1451 / 1456

页数：6

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