Genomic selection

被引：46

作者：

Fernando, R. L. ^{[1
,2
]}

Habier, D. ^{[1
]}

Stricker, C. ^{[3
]}

Dekkers, J. C. M. ^{[1
]}

Totir, L. R. ^{[4
]}

机构：

[1] Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA

[2] Iowa State Univ, Ctr Intergrated Anim Gen, Ames, IA 50011 USA

[3] Appl Genet Network, Davos, Switzerland

[4] Pioneer HiBred Int Inc, DuPont Business, Johnston, IA USA

来源：

ACTA AGRICULTURAE SCANDINAVICA SECTION A-ANIMAL SCIENCE | 2007年 / 57卷 / 04期

关键词：

Bayesian inference; BLUP; computer simulation; genetic evaluation; marker-assisted selection;

D O I：

10.1080/09064700801959395

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Computer simulation was used to examine the relationship between the number of loci included in the model and the accuracy of whole-genome methods for genetic evaluation. Random-regression BLUP (RR-BLUP) and Bayesian inference (Bayes-B) were compared with BLUP based on trait phenotypes and pedigree (TP-BLUP), where the genomic information consisted of genotypes at 110 or 2010 unlinked SNP loci. Of these loci, 10 were the actual trait loci. Accuracies for RR-BLUP were much higher than for TP-BLUP with 110 loci, but they were closer to TP-BLUP with 20 10 loci. Accuracies with Bayes-B were close to 1 with 110 or with 2010 loci. Results for Bayes-B were also examined with a range of 3000 to 60 000 markers in linkage disequilibrium on 30 chromosomes. Increasing the number of markers did not lower the accuracy of Bayes-B. Thus, Bayes-B seems to be well suited for whole-genome analyses with large numbers of loci. This may not be the case for RR-BLUP.

引用

页码：192 / 195

页数：4

共 7 条

[1] Fernando, 1998, P 6 WORLD C GEN APPL, P329
[2] Genomic-assisted prediction of genetic value with semiparametric procedures
Gianola, Daniel
Fernando, Rohan L.
Stella, Alessandra
[J]. GENETICS, 2006, 173 (03) : 1761 - 1776
[3] GODDARD ME, 1998, P 6 WORLD C GEN APPL, V26, P33
[4] LANDE R, 1990, GENETICS, V124, P743
[5] Meuwissen THE, 2001, GENETICS, V157, P1819
[6] Xu SZ, 2003, GENETICS, V163, P789
[7] Yi NJ, 2003, GENETICS, V165, P867

← 1 →