Structural and functional features of glycosyltransferases

被引：120

作者：

Breton, C

Mucha, J

Jeanneau, C

机构：

[1] Univ Grenoble 1, Ctr Rech Macromol Vegetales, CNRS, F-38041 Grenoble 9, France

[2] Univ Bodenkultur Wien, Zent Angew Genet, A-1190 Vienna, Austria

来源：

BIOCHIMIE | 2001年 / 83卷 / 08期

关键词：

glycosyltransferase; Golgi retention; domain structure; catalytic domain; stem;

D O I：

10.1016/S0300-9084(01)01298-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most of the glycosylation reactions that generate the great diversity of oligosaccharide structures of eukaryotic cells occur in the Golgi apparatus. This review deals with the most recent data that provide insight into the functional organization of Golgi-resident glycosyltransferases. We also focus on the recent successes in X-ray crystal structure determination of glycosyltransferases. These new structures begin to shed light on the molecular bases accounting for donor and acceptor substrate specificities as well as catalysis. (C) 2001 Societe francaise de biochimie et biologic moleculaire/Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：713 / 718

页数：6

共 37 条

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