LL-Z1271α:: An interleukin-1β production inhibitor

被引：4

作者：

Ichikawa, K

Inagaki, T

Kachi-Tonai, H

Kojima, Y

Nakamura, T

Nishida, H

Ueno, Y

Binding, P

Gabel, CA

Lucas, V

McNiff, PA

Kojima, N

机构：

[1] Pfizer Pharmaceut Inc, Nagoya Labs, PGRD, Aichi 4702393, Japan

[2] Pfizer Inc, Sandwich Labs, PGRD, Sandwich CT13 9NJ, Kent, England

[3] Pfizer Inc, Groton Labs, PGRD, Groton, CT 06340 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 286卷 / 04期

关键词：

D O I：

10.1006/bbrc.2001.5458

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LL-Z12711 alpha, a fungal metabolite, dose-dependently inhibited interleukin-1 beta (IL-1 beta) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271 alpha to LPS-challenged mice caused significant lowering in the IL-1 beta levels in peritoneal cavity. Data presented suggest that LL-Z1271 alpha inhibits IL-1 beta production by a novel mechanism as the inhibitory activity was not due to effects on caspase-1 (IL-1 beta converting enzyme), the ATP-induced release mechanism or a lysosomotrophic effect. (C) 2001 Academic Press.

引用

页码：697 / 700

页数：4

共 23 条

[1] Interleukin-1 receptor antagonist: Role in biology
Arend, WP
Malyak, M
Guthridge, CJ
Gabay, C
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 : 27 - 55
[2] INTERLEUKIN-1 RECEPTOR ANTAGONIST
AREND, WP
[J]. ADVANCES IN IMMUNOLOGY, VOL 54, 1993, 54 : 167 - 227
[3] MOLECULAR-CLONING OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME
CERRETTI, DP
KOZLOSKY, CJ
MOSLEY, B
NELSON, N
VANNESS, K
GREENSTREET, TA
MARCH, CJ
KRONHEIM, SR
DRUCK, T
CANNIZZARO, LA
HUEBNER, K
BLACK, RA
[J]. SCIENCE, 1992, 256 (5053) : 97 - 100
[4] Chantry D, 1989, Biotechnol Ther, V1, P361
[5] INTERLEUKIN-1 (IL-1) GENE-EXPRESSION, SYNTHESIS, AND EFFECT OF SPECIFIC IL-1 RECEPTOR BLOCKADE IN RABBIT IMMUNE-COMPLEX COLITIS
COMINELLI, F
NAST, CC
CLARK, BD
SCHINDLER, R
LLERENA, R
EYSSELEIN, VE
THOMPSON, RC
DINARELLO, CA
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (03) : 972 - 980
[6] Dinarello C A, 1998, Int Rev Immunol, V16, P457, DOI 10.3109/08830189809043005
[7] INFLAMMATORY CYTOKINES - INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR AS EFFECTOR MOLECULES IN AUTOIMMUNE-DISEASES
DINARELLO, CA
[J]. CURRENT OPINION IN IMMUNOLOGY, 1991, 3 (06) : 941 - 948
[8] STRUCTURE OF A C17 ANTIFUNGAL TERPENOID FROM AN UNIDENTIFIED ACROSTALAGMUS SPECIES
ELLESTAD, GA
EVANS, RH
KUNSTMANN, MP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1969, 91 (08) : 2134 - +
[9] Ferrari D, 1997, J IMMUNOL, V159, P1451
[10] GEIGER T, 1993, CLIN EXP RHEUMATOL, V11, P515

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