Progression of coronary artery calcification: A pilot study

被引:99
作者
Maher, JE
Bielak, LF
Raz, JA
Sheedy, PF
Schwartz, RS
Peyser, PA
机构
[1] Mayo Clin, Dept Diagnost Radiol, Rochester, MN 55905 USA
[2] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
[4] Mayo Clin, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA
关键词
D O I
10.4065/74.4.347
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To describe individual changes in the quantity of coronary artery calcification (CAC) measured by electron beam computed tomography (CT) and determine the rate of change in the quantity of CAC during a 3.5-year period, Material and Methods: Eighty-eight consecutive participants (51 men at least 30 years of age and 37 women at least 40 years of age) from a community-based CAC study were invited for a follow-up examination, Established coronary artery disease risk factors were studied at baseline. CAC score was measured by electron beam CT at baseline and follow-up. Results: Of the 88 invited participants, 82 (93%) returned for a follow-up examination. Considerable variation existed among the participants in the extent of CAC score change. On average, CAC score increased over time by an estimated 24% each year (P<0.05). The relative increase in CAC score over time was significantly lower for older than for younger participants but did not vary significantly by sex. Conclusion: The ability to recruit follow-up participants in this pilot study and to detect significant change in CAC score over time provides evidence that electron beam CT is useful for studying progression of CAC in a sample and may be a valuable procedure for assessing the effectiveness of clinical interventions designed to retard progression of coronary atherosclerosis.
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收藏
页码:347 / 355
页数:9
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