Problems with parsimony in sequences of biased base composition

被引：68

作者：

Eyre-Walker, A ^{[1
]}

机构：

[1] Univ Sussex, Ctr Study Evol, Brighton BN1 9QG, E Sussex, England

[2] Univ Sussex, Sch Biol Sci, Brighton BN1 9QG, E Sussex, England

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1998年 / 47卷 / 06期

关键词：

parsimony; G + C content; base composition; substitution pattern; mutation pattern;

D O I：

10.1007/PL00006427

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parsimony is commonly used to infer the direction of substitution and mutation. However, it is known that parsimony is biased when the base composition of the DNA sequence is skewed. Here I quantify this effect for several simple cases. The analysis demonstrates that parsimony can be misleading even when levels of sequence divergence are as low as 10%; parsimony incorrectly infers an excess of common to rare changes. Caution must therefore be excercised in the use of parsimony.

引用

页码：686 / 690

页数：5

共 12 条

[1]

AKASHI H, 1995, GENETICS, V139, P1067

[2]

BALLARD JWO, 1994, GENETICS, V138, P757

[3] COMPOSITIONAL BIAS, CHARACTER-STATE BIAS, AND CHARACTER-STATE RECONSTRUCTION USING PARSIMONY [J].