Isolation and structural characterization of a peptide from the venom of scorpion with toxicity towards invertebrates and vertebrates

被引：11

作者：

Corzo, G ^{[1
]}

Villegas, E ^{[1
]}

Nakajima, T ^{[1
]}

机构：

[1] Suntory Inst Bioorgan Res, Osaka 6188503, Japan

来源：

PROTEIN AND PEPTIDE LETTERS | 2001年 / 8卷 / 05期

关键词：

D O I：

10.2174/0929866013409256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using a methodology based on HPLC fractionation, mass spectrometry analysis, and microinjection guide-bioassays, a peptide with toxicity to both insects and mammals was isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus, and named LqhIV (after LqhII and LqhIII[1]). The primary sequence, circular dichroism spectrum and three-dimensional structure simulation of LqhIV indicate that it contains similar structure to that of the group of alpha scorpion toxins.

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页码：385 / 393

页数：9

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