Responsiveness to interferon alpha treatment in patients with chronic hepatitis C coinfected with hepatitis G virus

被引:71
作者
Berg, T
Dirla, U
Naumann, U
Heuft, HG
Kuther, S
Lobeck, H
Schreier, E
Hopf, U
机构
[1] HUMBOLDT UNIV BERLIN, KLINIKUM RUDOLF VIRCHOW, ABT INNERE MED, DEPT INTERNAL MED, D-13353 BERLIN, GERMANY
[2] ROBERT KOCH INST, D-1000 BERLIN, GERMANY
[3] HUMBOLDT UNIV BERLIN, DEPT PATHOL, BERLIN, GERMANY
关键词
GB virus C; helicase region; hepatitis C virus; hepatitis G virus; interferon alpha;
D O I
10.1016/S0168-8278(96)80250-9
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Patients with chronic hepatitis C are often coinfected with the new identified Flaviviridae-like agent, termed hepatitis G virus (HGV), The aim of the study was to investigate the responsiveness of hepatitis G virus to interferon alpha and to evaluate whether a hepatitis G virus coinfection negatively influences the outcome of treatment in chronic hepatitis C, Methods: One hundred and fifteen patients with histologically proven chronic hepatitis C were treated with interferon alpha and investigated for the presence of hepatitis G virus coinfection by nested polymerase chain reaction with primers from the helicase region of hepatitis G virus, All patients received at least 3 MU (range 3-6) interferon alpha thrice weekly for at least 6 months (mean 8, range 6-12), Polymerase chain reaction products of seven pre- and post-treatment hepatitis G virus positive patients were directly sequenced for identification of sequence variability during the follow-up, Results: Eighteen (16%) patients were coinfected with hepatitis G virus, Although nine (50%) of these patients became HGV RNA negative during interferon alpha therapy, only three patients (17%) remained HGV RNA negative at the end of follow-up (mean 24 months), The rate of sustained response of chronic hepatitis C was not significantly different between patients with hepatitis C virus infection and HCV/HGV coinfection (19% vs 28%), Severity of liver disease as determined by alanine aminotransferase levels, histology and hepatitis C virus viremia was not significantly different in patients with hepatitis C virus or HCV/ HGV coinfection, Sequence analysis of the helicase region revealed that our isolates all belonged to the hepatitis G virus and not to the GBV-C like genotype, No amino acid exchanges during the observation period of up to 48 months were observed, indicating that this region is highly conserved, Conclusions: The responsiveness of hepatitis G virus to interferon alpha in chronic HCV/HGV coinfected patients is similar to that observed in chronic hepatitis C, Hepatitis G virus coinfection seems not to interfere with the efficacy of interferon alpha treatment in patients with chronic hepatitis C.
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页码:763 / 768
页数:6
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