Coupling between neuronal firing, field potentials, and fMR1 in human auditory cortex

被引：721

作者：

Mukamel, R

Gelbard, H

Arieli, A

Hasson, U

Fried, I

Malach, R ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Neurosurg, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA

[3] NYU, Ctr Neural Sci, New York, NY 10003 USA

[4] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

[5] Tel Aviv Univ, Tel Aviv Med Ctr, Funct Neurosurg Unit, IL-69978 Tel Aviv, Israel

[6] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

来源：

SCIENCE | 2005年 / 309卷 / 5736期

关键词：

D O I：

10.1126/science.1110913

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Functional magnetic resonance imaging (fMRI) is an important tool. for investigating human brain function, but the relationship between the hemodynamicatly based fMRI signals in the human brain and the underlying neuronal activity is unclear. We recorded single unit activity and local field potentials in auditory cortex of two neurosurgical patients and compared them with the fMRI signals of 11 healthy subjects during presentation of an identical movie segment. The predicted fMRI signals derived from single units and the measured fMRI signals from auditory cortex showed a highly significant correlation (r = 0.7S, P <10(-47)). Thus, fMRI signals can provide a reliable measure of the firing rate of human cortical neurons.

引用

页码：951 / 954

页数：4

共 28 条

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