Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis

被引：54

作者：

Alberola, J ^{[1
]}

Rodríguez, A

Francino, O

Roura, X

Rivas, L

Andreu, D

机构：

[1] Univ Autonoma Barcelona, Fac Vet, Dept Farmacol Terapeut & Toxicol, Barcelona 08193, Spain

[2] Univ Autonoma Barcelona, Fac Vet, Dept Ciencias Anim & Aliments, Barcelona 08193, Spain

[3] Univ Autonoma Barcelona, Fac Vet, Hosp Clin Vet, Barcelona 08193, Spain

[4] Ctr Invest Biol, E-28006 Madrid, Spain

[5] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona 08003, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 02期

关键词：

D O I：

10.1128/AAC.48.2.641-643.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis.

引用

页码：641 / 643

页数：3

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