Rapid evolution of H5N1 influenza viruses in chickens in Hong Kong

被引:104
作者
Zhou, NN
Shortridge, KF
Claas, ECJ
Krauss, SL
Webster, RG [1 ]
机构
[1] St Jude Childrens Res Hosp, Dept Virol & Mol Biol, 332 N Lauderdale St, Memphis, TN 38105 USA
[2] Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Peoples R China
[3] Jiangxi Med Coll, Dept Microbiol, Nanchang, Peoples R China
[4] Leiden Univ, Med Ctr, Dept Virol, Leiden, Netherlands
关键词
D O I
10.1128/JVI.73.4.3366-3374.1999
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The H5N1 avian influenza virus that killed 6 of 18 persons infected in Hong Kong in 1997 was transmitted directly from poultry to humans. Viral isolates From this outbreak may provide molecular clues to zoonotic transfer. Here me demonstrate that the H5N1 viruses circulating in poultry comprised two distinguishable phylogenetic lineages in all genes that were in very rapid evolution, When introduced into new hosts, influenza viruses usually undergo rapid alteration of their surface glycoproteins, especially in the hemagglutinin (HA). Surprisingly, these H5N1 isolates had a large proportion of amino acid changes in all gene products except in the HA. These viruses maybe reassortants each of whose HA gene is well adapted to domestic poultry while the rest of the genome arises from a different source, The consensus amino acid sequences of "internal" virion proteins reveal amino acids previously found in human strains. These human-specific amino acids may be important factors in zoonotic transmission.
引用
收藏
页码:3366 / 3374
页数:9
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