Alzheimer's disease related copper(II)-β-amyloid peptide exhibits phenol monooxygenase and catechol oxidase activities

被引：43

作者：

da Silva, GFZ

Ming, LJ

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Univ S Florida, Inst Biomol Sci, Tampa, FL 33620 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 34期

关键词：

beta-amyloids; Alzheimer's disease; copper; oxidoreductases; pepticles; redox chemistry;

D O I：

10.1002/anie.200501013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A gray area in gray matter: The Cu II complex of a truncated β-amyloid, CuAβ1-20, catalyzes the oxidation of catechol and the hydroxylation and oxidation of phenol (see picture) with dramatic rate accelerations (≈ 10 5-106-fold increases). The Cu-oxygen chemistry of CuAβ may offer both a better understanding of the chemical effect in the brains of patients who suffer from Alzheimer's disease as well as possible treatment strategies of this disease. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5501 / 5504

页数：4

共 26 条

[1] The metallobiology of Alzheimer's disease
Bush, AI
[J]. TRENDS IN NEUROSCIENCES, 2003, 26 (04) : 207 - 214
[2] Catechol oxidase-like oxidation chemistry of the 1-20 and 1-16 fragments of Alzheimer's disease-related β-amyloid peptide -: Their structure-activity correlation and the fate of hydrogen peroxide
da Silva, GFZ
Tay, WM
Ming, LJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (17) : 16601 - 16609
[3] Catecholamines potentiate amyloid β-peptide neurotoxicity:: Involvement of oxidative stress, mitochondrial dysfunction, and perturbed calcium homeostasis
Fu, WM
Luo, H
Parthasarathy, S
Mattson, MP
[J]. NEUROBIOLOGY OF DISEASE, 1998, 5 (04) : 229 - 243
[4] Mechanistic insight into the catechol oxidase activity by a biomimetic dinuclear copper complex
Granata, A
Monzani, E
Casella, L
[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2004, 9 (07): : 903 - 913
[5] The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
Huang, XD
Atwood, CS
Hartshorn, MA
Multhaup, G
Goldstein, LE
Scarpa, RC
Cuajungco, MP
Gray, DN
Lim, J
Moir, RD
Tanzi, RE
Bush, AI
[J]. BIOCHEMISTRY, 1999, 38 (24) : 7609 - 7616
[6] Kinetics and thermodynamics of copper(I)/dioxygen interaction
Karlin, KD
Kaderli, S
Zuberbuhler, AD
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1997, 30 (03) : 139 - 147
[7] Leskovac V., 2002, COMPREHENSIVE ENZYME, P119
[8] Reactivity of dioxygen-copper systems
Lewis, EA
Tolman, WB
[J]. CHEMICAL REVIEWS, 2004, 104 (02) : 1047 - 1076
[9] Copper(II)-mediated autoxidation of tert-butylresorcinols
Ling, KQ
Lee, YH
Macikenas, D
Protasiewicz, JD
Sayre, LM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (04) : 1358 - 1366
[10] Manton Kenneth G., 2004, Current Alzheimer Research, V1, P277, DOI 10.2174/1567205043332036

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