Interferon-lambda and therapy for chronic hepatitis C virus infection

被引：72

作者：

Donnelly, Raymond P. ^{[1
]}

Dickensheets, Harold ^{[1
]}

O'Brien, Thomas R. ^{[2
]}

机构：

[1] US FDA, Div Therapeut Prot, Ctr Drug Evaluat & Res, Bethesda, MD 20892 USA

[2] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN IMMUNOLOGY | 2011年 / 32卷 / 09期

基金：

美国国家卫生研究院;

关键词：

REGULATORY FACTOR FAMILY; IFN-LAMBDA; GENETIC-VARIATION; DENDRITIC CELLS; DIFFERENTIAL EXPRESSION; ANTIVIRAL RESPONSES; VIRAL-INFECTION; INTERLEUKIN; 28B; III IFN; NON-A;

D O I：

10.1016/j.it.2011.07.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Interferon (IFN)-alpha, a type-I IFN, is widely used to treat chronic hepatitis C virus infection, but the broad expression of IFN-alpha receptors often leads to adverse reactions in many organs. Here, we examine IFN-lambda, a type-III IFN, as a therapeutic alternative to IFN-alpha. Like IFN-alpha, IFN-lambda also induces antiviral activity in hepatocytes, but might induce fewer adverse reactions because its receptor is largely restricted to cells of epithelial origin. We also discuss the recent discovery of single nucleotide polymorphisms (SNPs) near the human IFN-lambda 3 gene, IL28B, that correlate strongly with the ability to achieve a sustained virological response to therapy with pegylated IFN-alpha plus ribavirin in patients with chronic hepatitis C.

引用

页码：443 / 450

页数：8

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