Estrogen regulation of gene expression in the teleost fish immune system

被引：123

作者：

Alberto Burgos-Aceves, Mario ^{[1
]}

Cohen, Amit ^{[2
]}

Smith, Yoav ^{[2
]}

Faggio, Caterina ^{[3
]}

机构：

[1] Ctr Invest Biol Noroeste SC, Mar Bermejo 195,Col Playa Palo Sta Rita, La Paz 23090, Bcs, Mexico

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Genom Data Anal Unit, POB 12272, IL-91120 Jerusalem, Israel

[3] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale F Stagno dAlcontres 31, I-98166 Messina, Italy

来源：

FISH & SHELLFISH IMMUNOLOGY | 2016年 / 58卷

关键词：

Sex hormones; Immune system; Teleosts; microRNAs; Estrogen receptors; SPARUS-AURATA L; ENDOCRINE-DISRUPTING CHEMICALS; GILTHEAD SEABREAM; RECEPTOR-ALPHA; RAINBOW-TROUT; IN-VIVO; MICRORNA EXPRESSION; STEROID-HORMONES; ENVIRONMENTAL CONCENTRATIONS; DIFFERENTIAL EXPRESSION;

D O I：

10.1016/j.fsi.2016.09.006

中图分类号：

S9 [水产、渔业];

学科分类号：

090805 [渔业资源学];

摘要：

Elucidating the mechanisms of estrogens-induced immunomodulation in teleost fish is of great importance due to the observed worldwide continuing decrease in pristine environments. However, little is know about the immunotoxicological consequences of exposure to these chemicals in fish, or of the mechanisms through which these effects are mediated. In this review, we summarize the results showing estrogens (natural or synthetic) acting through estrogen receptors and regulating specific target genes, also through microRNAs (miRNAs), leading to modulation of the immune functioning. The identification and characterization of miRNAs will provide new opportunities for functional genome research on teleost immune system and can also be useful when screening for novel molecule biomarkers for environmental pollution. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：42 / 49

页数：8

共 150 条

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Expression and regulation of miR-17a and miR-430b in zebrafish ovarian follicles [J].