Light absorption of (oxy-)hemoglobin assessed by spectroscopic optical coherence tomography

被引:134
作者
Faber, DJ
Mik, EG
Aalders, MCG
van Leeuwen, TG
机构
[1] Univ Amsterdam, Acad Med Ctr, Ctr Laser, NL-1100 DE Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Physiol, NL-1100 DE Amsterdam, Netherlands
[3] Univ Twente, Biophys Engn Biomed Technol Inst, NL-7500 AE Enschede, Netherlands
关键词
D O I
10.1364/OL.28.001436
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
The combination of optical coherence tomography and spectroscopy may allow for highly localized, quantitative measurements of tissue spectral properties. We present, for the first time to our knowledge, quantitative measurements of the absorption coefficients of phantoms and of hemoglobin and oxygenated hemoglobin with spectroscopic optical coherence tomography (SOCT). Our results suggest that SOCT will be able to provide localized, quantitative oxygenation measurements. (C) 2003 Optical Society of America.
引用
收藏
页码:1436 / 1438
页数:3
相关论文
共 12 条
[1]   Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography [J].
deBoer, JF ;
Milner, TE ;
vanGemert, MJC ;
Nelson, JS .
OPTICS LETTERS, 1997, 22 (12) :934-936
[2]   OPTICAL COHERENCE MICROSCOPY IN SCATTERING MEDIA [J].
IZATT, JA ;
HEE, MR ;
OWEN, GM ;
SWANSON, EA ;
FUJIMOTO, JG .
OPTICS LETTERS, 1994, 19 (08) :590-592
[3]   In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomograghy [J].
Izatt, JA ;
Kulkami, MD ;
Yazdanfar, S ;
Barton, JK ;
Welch, AJ .
OPTICS LETTERS, 1997, 22 (18) :1439-1441
[4]  
KULKARNI MD, 1996, 1996 OSA TECHNICAL D, V9, P59
[5]   Spectral measurement of absorption by spectroscopic frequency-domain optical coherence tomography [J].
Leitgeb, R ;
Wojtkowski, M ;
Kowalczyk, A ;
Hitzenberger, CK ;
Sticker, M ;
Fercher, AF .
OPTICS LETTERS, 2000, 25 (11) :820-822
[6]   Spectroscopic optical coherence tomography [J].
Morgner, U ;
Drexler, W ;
Kärtner, FX ;
Li, XD ;
Pitris, C ;
Ippen, EP ;
Fujimoto, JG .
OPTICS LETTERS, 2000, 25 (02) :111-113
[7]   In vivo video rate optical coherence tomography [J].
Rollins, AM ;
Kulkarni, MD ;
Yazdanfar, S ;
Ung-arunyawee, R ;
Izatt, JA .
OPTICS EXPRESS, 1998, 3 (06) :219-229
[8]   Differential absorption imaging with optical coherence tomography [J].
Schmitt, JM ;
Xiang, SH ;
Yung, KM .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1998, 15 (09) :2288-2296
[9]   Assessment of regional tissue oxygenation [J].
Siegemund, M ;
van Bommel, J ;
Ince, C .
INTENSIVE CARE MEDICINE, 1999, 25 (10) :1044-1060
[10]  
VANLEEUWEN TG, 1999, OSA TECHNICAL DIGEST