Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations

被引：16

作者：

La Spina, I

Porazzi, D

Maggiolo, F

Bottura, P

Suter, F

机构：

[1] Osped Civile, Dept Neurol, I-21052 Busto Arsizio, Italy

[2] Civil Hosp, Dept Infect Dis, I-21052 Busto Arsizio, Italy

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2001年 / 8卷 / 01期

关键词：

Gabapentin; HIV; peripheral neuropathy;

D O I：

10.1046/j.1468-1331.2001.00157.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The objective of this study was to assess the efficacy and safety of Gabapentin as the sole analgesic in patients with HIV-related painful neuropathy. Nineteen patients with HIV-related painful neuropathy were administered Gabapentin. Efficacy was evaluated with two 100-mm Visual Analogue Scales (VAS) (0: no symptom I 100: worst symptom), rating pain and interference of pain with sleep, performed at baseline and monthly intervals. Main Pain VAS score decreased from a baseline of 55.7 +/- 19.1 mm to a final 14.7 +/- 18.6 mm (ANOVA P = 0.0001) and mean Sleep Interference VAS score decreased From a baseline of 60.4 +/- 31.9 mm to a final 15.5 +/- 27.7 mm (ANOVA P = 0.0001). Gabapentin provided significant pain relief in our patients with HIV-associated painful sensory neuropathy.

引用

页码：71 / 75

页数：5

共 26 条

[1] Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus - A randomized controlled trial [J].