A new route to functionalised π-allyltricarbonyliron lactam complexes from aziridines and their use in stereoselective synthesis and oxidative conversion to β-lactams

被引：32

作者：

Ley, SV ^{[1
]}

Middleton, B ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 18期

关键词：

D O I：

10.1039/a806236f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aziridinyl enones can be converted in good yield into pi-allyltricarbonyliron lactam complexes bearing ketone functionality in the side chain; addition of a variety of nucleophiles into the side chains of these complexes proceeds in good yield and excellent (> 95%) de to afford secondary and tertiary alcohols which on treatment with trimethylamine N-oxide form the corresponding beta-lactams in good yield.

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页码：1995 / 1996

页数：2

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