BEHAB/brevican: A brain-specific lectican implicated in gliomas and glial cell motility

被引：44

作者：

Gary, SC ^{[1
]}

Kelly, GM ^{[1
]}

Hockfield, S ^{[1
]}

机构：

[1] Yale Univ, Neurobiol Sect, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(98)80083-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Several recent findings have advanced our understanding of the composition and function of the brain extracellular matrix (ECM). BEHAB/brevican, a recently identified CNS-specific proteoglycan, is a component of the brain ECM and is upregulated during glial cell motility. it is expressed at high levels during development, in response to injury, and in primary brain tumors. Cleavage of the BEHAB/brevican protein may increase invasion of tumor cells.

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页码：576 / 581

页数：6

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