The Default Mode Network In Late-Life Anxious Depression

被引：63

作者：

Andreescu, Carmen ^{[2
]}

Wu, Minjie

Butters, Meryl A. ^{[2
]}

Figurski, Jennifer ^{[2
]}

Reynolds, Charles F., III ^{[2
]}

Aizenstein, Howard J. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Dept Bioengn, Western Psychiat Inst, Med Ctr, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Psychiat, Med Ctr, Pittsburgh, PA 15213 USA

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2011年 / 19卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Default mode network; anxious depression; elderly; functional connectivity; ANXIETY; BRAIN; RISK;

D O I：

10.1097/JGP.0b013e318227f4f9

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: The aim of this exploratory study is to examine the default mode network (DMN) functional connectivity pattern in elderly depressed subjects with and without comorbid anxiety. Methods: Functional magnetic resonance imaging data were collected for 11 elderly depressed subjects with high comorbid anxiety and eight elderly depressed subjects with low anxiety. We analyzed the resting-connectivity patterns of the posterior cingulate cortex. We compared the DMN activity in the elderly depressed subjects with high versus low comorbid anxiety. Results: Depressed elderly with high comorbid anxiety had increased functional connectivity in the posterior regions of the DMN and decreased functional connectivity in the anterior regions of the DMN. Conclusions: Elderly depressed subjects with high anxiety display a dissociative pattern of connectivity in the DMN when compared with elderly depressed subjects with low anxiety. These results suggest a unique biologic signature of the anxiety symptoms in the context of late-life depression. (Am J Geriatr Psychiatry 2011; 19:980-983)

引用

页码：980 / 983

页数：4

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