The Role of Retinoic Acid in Tolerance and Immunity

被引：443

作者：

Hall, Jason A. ^{[1
,2
]}

Grainger, John R. ^{[1
]}

Spencer, Sean P. ^{[1
,2
]}

Belkaid, Yasmine ^{[1
]}

机构：

[1] NIAID, Mucosal Immun Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Penn, Immunol Grad Grp, Philadelphia, PA 19104 USA

来源：

IMMUNITY | 2011年 / 35卷 / 01期

基金：

美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; CD103(+) DENDRITIC CELLS; VITAMIN-A-DEFICIENCY; LAMINA-PROPRIA; X-RECEPTOR; FUNCTIONAL SPECIALIZATION; FOXP3; EXPRESSION; SMALL-INTESTINE; DOWN-REGULATION; TH17; CELLS;

D O I：

10.1016/j.immuni.2011.07.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitamin A elicits a broad array of immune responses through its metabolite, retinoic acid (RA). Recent evidence indicates that loss of RA leads to impaired immunity, whereas excess RA can potentially promote inflammatory disorders. In this review, we discuss recent advances showcasing the crucial contributions of RA to both immunological tolerance and the elicitation of adaptive immune responses. Further, we provide a comprehensive overview of the cell types and factors that control the production of RA and discuss how host perturbations may affect the ability of this metabolite to control tolerance and immunity or to instigate pathology.

引用

页码：13 / 22

页数：10

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