Characterization of mosquito-adapted West Nile virus
被引:43
作者:
Ciota, Alexander T.
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New York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USANew York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USA
Ciota, Alexander T.
[1
]
Lovelace, Amy O.
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New York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USANew York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USA
Lovelace, Amy O.
[1
]
Jia, Yongqing
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New York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USANew York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USA
Jia, Yongqing
[1
]
Davis, Lauren J.
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New York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USANew York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USA
Davis, Lauren J.
[1
]
Young, David S.
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New York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USANew York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USA
Young, David S.
[1
]
Kramer, Laura D.
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New York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USA
SUNY Albany, Sch Publ Hlth, Albany, NY USANew York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USA
Kramer, Laura D.
[1
,2
]
机构:
[1] New York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USA
West Nile virus (WNV), a mosquito-borne flavivirus, has significantly expanded its geographical and host range since its 1999 introduction into North America. The underlying mechanisms of evolution of WNV and other arboviruses are still poorly understood. Studies evaluating virus adaptation and fitness in relevant in vivo systems are largely lacking. In order to evaluate the capacity for host-specific adaptation and the genetic correlates of adaptation in vivo, this study measured phenotypic and genotypic changes in WNV resulting from passage in Culex pipiens mosquitoes. An increase in replicative ability of WNV in C. pipiens was attained for the two lineages of WNV tested. This adaptation for replication in mosquitoes did not result in a replicative cost in chickens, but did decrease cell-to-cell spread of virus in vertebrate cell culture. Genetic analyses of one mosquito-adapted lineage revealed a total of nine consensus nucleotide substitutions with no accumulation of a significant mutant spectrum. These results differed significantly from previous in vitro studies. When St Louis encephalitis virus (SLEV), a closely related flavivirus, was passaged in C. pipiens, moderately attenuated growth in C. pipiens was observed for two lineages tested. These results suggest that significant differences in the capacity for mosquito adaptation may exist between WNV and SLEV, and demonstrate that further comparative studies in relevant in vivo systems will help elucidate the still largely unknown mechanisms of arboviral adaptation in ecologically relevant hosts.
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Ciota, Alexander T.
Lovelace, Amy O.
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New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Lovelace, Amy O.
Ngo, Kiet A.
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New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Ngo, Kiet A.
Le, An N.
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New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Le, An N.
Maffei, Joseph G.
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New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Maffei, Joseph G.
Franke, Mary A.
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New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Franke, Mary A.
Payne, Anne F.
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New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Payne, Anne F.
Jones, Susan A.
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New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Jones, Susan A.
Kauffman, Elizabeth B.
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New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Kauffman, Elizabeth B.
Kramer, Laura D.
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New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Ciota, Alexander T.
Lovelace, Amy O.
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机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Lovelace, Amy O.
Ngo, Kiet A.
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h-index: 0
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Ngo, Kiet A.
Le, An N.
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h-index: 0
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Le, An N.
Maffei, Joseph G.
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h-index: 0
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Maffei, Joseph G.
Franke, Mary A.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Franke, Mary A.
Payne, Anne F.
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h-index: 0
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Payne, Anne F.
Jones, Susan A.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Jones, Susan A.
Kauffman, Elizabeth B.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA
Kauffman, Elizabeth B.
Kramer, Laura D.
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h-index: 0
机构:
New York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USANew York State Dept Hlth, Arbovirus Labs, Wadsworth Ctr, Slingerlands, NY 12159 USA