Leukocyte alkaline phosphatase a specific marker for the post-mitotic neutrophilic granulocyte: Regulation in acute promyelocytic leukemia

被引:19
作者
Garattini, E
Gianni, M
机构
[1] Molecular Biology Unit, Ctro. Catullo Daniela Borgomainerio, Ist. Ric. Farmacologiche Mario Negri, Milano
[2] Molecular Biology Unit, Ctro. Catullo Daniela Borgomainerio, Ist. Ric. Farmacologiche, Mario N., 20157 Milano
关键词
retinoic acid; alkaline phosphatase; acute promyelocytic; leukemia; G-CSF; cAMP; cyto-differentiation;
D O I
10.3109/10428199609054858
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Leukocyte alkaline phosphatase (LAP) is the product of the gene coding for the liver/bone/kidney-type alkaline phosphatase. In the normal hematopoietic system, the only cell type expressing LAP in basal conditions is the post mitotic neutrophilic granulocyte. Thus LAP represents a spe cific and restrictive marker for the terminal maturation of the neutrophilic granulocyte. The study of the factors and the molecular mechanisms responsible for the expression of LAP in cells undergoing granulocytic maturation may shed light on this complex biological process. Acute promyelocytic leukemia (APL) represents a unique biological model in which it is possible to investigate neutrophilic differentiation. APL blasts undergo rapid and irreversible maturation towards cells morphologically and biochemically resembling normal mature granulocytes upon in vivo and in vitro challenge with all-trans retinoic acid (ATRA). In this cellular context, we studied the endogenous factors involved in the expression of LAP. The phosphatase is not synthesized in undifferentiated APL blasts and it is expressed only upon treatment with combinations between ATRA and a second cyto-differentiating signal. The second signal may be given by G-CSF, cAMP analogs, IL-6 and to a lesser extent by IL-1 beta. The molecular mechanisms underlying the induction of LAP by combinations of ATRA and G-CSF or cAMP analogs were studied in detail and are the object of this review.
引用
收藏
页码:493 / 503
页数:11
相关论文
共 73 条
[1]   THE UPSTREAM REGION OF THE HUMAN HOMEOBOX GENE HOX3D IS A TARGET FOR REGULATION BY RETINOIC ACID AND HOX HOMEOPROTEINS [J].
ARCIONI, L ;
SIMEONE, A ;
GUAZZI, S ;
ZAPPAVIGNA, V ;
BONCINELLI, E ;
MAVILIO, F .
EMBO JOURNAL, 1992, 11 (01) :265-277
[2]   INDUCTION OF MONOCYTIC DIFFERENTIATION AND BONE-RESORPTION BY 1,25-DIHYDROXYVITAMIN-D3 [J].
BARSHAVIT, Z ;
TEITELBAUM, SL ;
REITSMA, P ;
HALL, A ;
PEGG, LE ;
TRIAL, J ;
KAHN, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (19) :5907-5911
[3]   CLONING AND SEQUENCING OF HUMAN INTESTINAL ALKALINE-PHOSPHATASE CDNA [J].
BERGER, J ;
GARATTINI, E ;
HUA, JC ;
UDENFRIEND, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (03) :695-698
[4]   CONVERSION OF PLACENTAL ALKALINE-PHOSPHATASE FROM A PHOSPHATIDYLINOSITOL-GLYCAN-ANCHORED PROTEIN TO AN INTEGRAL TRANSMEMBRANE PROTEIN [J].
BERGER, J ;
MICANOVIC, R ;
GREENSPAN, RJ ;
UDENFRIEND, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (05) :1457-1460
[5]   CHANGES IN SUBCELLULAR-LOCALIZATION AND SURFACE EXPRESSION OF L-SELECTIN, ALKALINE-PHOSPHATASE, AND MAC-1 IN HUMAN NEUTROPHILS DURING STIMULATION WITH INFLAMMATORY MEDIATORS [J].
BORREGAARD, N ;
KJELDSEN, L ;
SENGELOV, H ;
DIAMOND, MS ;
SPRINGER, TA ;
ANDERSON, HC ;
KISHIMOTO, TK ;
BAINTON, DF .
JOURNAL OF LEUKOCYTE BIOLOGY, 1994, 56 (01) :80-87
[6]   IDENTIFICATION OF A HIGHLY MOBILIZABLE SUBSET OF HUMAN NEUTROPHIL INTRACELLULAR VESICLES THAT CONTAINS TETRANECTIN AND LATENT ALKALINE-PHOSPHATASE [J].
BORREGAARD, N ;
CHRISTENSEN, L ;
BJERRUM, OW ;
BIRGENS, HS ;
CLEMMENSEN, I .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (02) :408-416
[7]   MOLECULAR ANALYSIS OF ACUTE PROMYELOCYTIC LEUKEMIA BREAKPOINT CLUSTER REGION ON CHROMOSOME-17 [J].
BORROW, J ;
GODDARD, AD ;
SHEER, D ;
SOLOMON, E .
SCIENCE, 1990, 249 (4976) :1577-1580
[8]   INDUCTION OF DIFFERENTIATION OF THE HUMAN PROMYELOCYTIC LEUKEMIA-CELL LINE (HL-60) BY RETINOIC ACID [J].
BREITMAN, TR ;
SELONICK, SE ;
COLLINS, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (05) :2936-2940
[9]  
CASTAGNA M, 1982, J BIOL CHEM, V257, P7847
[10]  
CASTAIGNE S, 1990, BLOOD, V76, P1704