Finite scale of spatial representation in the hippocampus

被引：464

作者：

Kjelstrup, Kirsten Brun ^{[1
,2
]}

Solstad, Trygve ^{[1
,2
]}

Brun, Vegard Heimly ^{[1
,2
]}

Hafting, Torkel ^{[1
,2
]}

Leutgeb, Stefan ^{[1
,2
]}

Witter, Menno P. ^{[1
,2
,3
]}

Moser, Edvard I. ^{[1
,2
]}

Moser, May-Britt ^{[1
,2
]}

机构：

[1] Norwegian Univ Sci & Technol, Kavli Inst Syst Neurosci, N-7489 Trondheim, Norway

[2] Norwegian Univ Sci & Technol, Ctr Biol Memory, N-7489 Trondheim, Norway

[3] Vrije Univ Amsterdam Med Ctr, Dept Anat & Neurosci, Neurosci Res Inst, NL-1007 MB Amsterdam, Netherlands

来源：

SCIENCE | 2008年 / 321卷 / 5885期

关键词：

D O I：

10.1126/science.1157086

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To determine how spatial scale is represented in the pyramidal cell population of the hippocampus, we recorded neural activity at multiple longitudinal levels of this brain area while rats ran back and forth on an 18- meter- long linear track. CA3 cells had well- defined place fields at all levels. The scale of representation increased almost linearly from <1 meter at the dorsal pole to similar to 10 meters at the ventral pole. The results suggest that the place- cell map includes the entire hippocampus and that environments are represented in the hippocampus at a topographically graded but finite continuum of scales.

引用

页码：140 / 143

页数：4

共 35 条

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