Heterogeneity in the muscle satellite cell population

被引:120
作者
Biressi, Stefano [1 ]
Rando, Thomas A. [1 ,2 ]
机构
[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[2] VA Palo Alto Hlth Care Syst, Neurol Serv, Palo Alto, CA 94304 USA
关键词
Satellite cell; Heterogeneity; Muscle; Regeneration; Lineage; Stem cell; MYOSIN HEAVY-CHAIN; MYOGENIC STEM-CELL; DISTINCT REGULATORY CASCADES; HUMAN SKELETAL-MUSCLE; ADULT BONE-MARROW; GENE-EXPRESSION; IN-VITRO; SELF-RENEWAL; MOUSE MUSCLE; MOLECULAR SIGNATURE;
D O I
10.1016/j.semcdb.2010.09.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Satellite cells, the adult stem cells responsible for skeletal muscle regeneration, are defined by their location between the basal lamina and the fiber sarcolemma. Increasing evidence suggests that satellite cells represent a heterogeneous population of cells with distinct embryological origin and multiple levels of biochemical and functional diversity. This review focuses on the rich diversity of the satellite cell population based on studies across species. Ultimately, a more complete characterization of the heterogeneity of satellite cells will be essential to understand the functional significance in terms of muscle growth, homeostasis, tissue repair, and aging. Published by Elsevier Ltd.
引用
收藏
页码:845 / 854
页数:10
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