Gold-catalyzed hydroxy- and alkoxycyclization of functionalized enynes

被引：58

作者：

Genin, Emilie ^{[1
]}

Leseurre, Lucie ^{[1
]}

Toullec, Patrick Yves ^{[1
]}

Genet, Jean-Pierre ^{[1
]}

Michelet, Veronique ^{[1
]}

机构：

[1] Ecole Natl Super Chim Paris, UMR 7573, Lab Synth Select Organ Prod Nat, F-75231 Paris 05, France

来源：

SYNLETT | 2007年 / 11期

关键词：

gold; cycloisomerization; enyne; atom economy; alkoxycyclization;

D O I：

10.1055/s-2007-982570

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general Au-III catalytic system is described for the efficient hydroxy- and alkoxycyclization reactions of 1,6-enynes. The reactions lead to carbo- and heterocyclic alcohols or ethers in good to excellent yields. The cyclizations are conducted in the presence of AuCl3/AgSbF6/PPh3 catalyst in dioxane-water or various alcohols at room temperature. The hydroxycyclization reactions of 1,7-enynes afforded either the methyl ketone or a mixture of the methyl ketone and the carbocyclic alcohol.

引用

页码：1780 / 1784

页数：5

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