Polymorphism in tumor necrosis factor genes associated with myasthenia gravis

被引：27

作者：

Hjelmstrom, P

Peacock, CS

Giscombe, R

Pirskanen, R

Lefvert, AK

Blackwell, JM

Sanjeevi, CB ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Hosp, Dept Mol Med, S-17176 Stockholm, Sweden

[2] Univ Cambridge, Addenbrookes Hosp, Sch Clin, Dept Med, Cambridge CB2 2QQ, England

[3] Karolinska Inst, Karolinska Hosp, Dept Med, S-17176 Stockholm, Sweden

[4] Karolinska Inst, Soder Hosp, Dept Neurol, S-11883 Stockholm, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 88卷 / 1-2期

基金：

英国惠康基金;

关键词：

myasthenia gravis; HLA; TNF; lymphotoxin;

D O I：

10.1016/S0165-5728(98)00107-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this study was to analyze associations between myasthenia gravis (MG) and polymorphisms in the tumor necrosis factor (TNF) region in 79 Swedish patients and 155 unrelated controls. The frequency of the TNFa2 allele of a microsatellite located 3.5 kb upstream of the lymphotoxin alpha (LT-alpha) gene in the TNF region was found to be increased in overall MG patients compared to controls. The frequency of the short 5.5 kb fragment (TNFB *1) of a bi-allelic NcoI RFLP polymorphism located at the first intron of the LT-a gene was increased in patients with an early onset of disease compared to patients with a later onset. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：137 / 143

页数：7

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