Polysomnogram changes in marijuana users who report sleep disturbances during prior abstinence

被引：45

作者：

Bolla, Karen I. ^{[1
,2
,3
]}

Lesage, Suzanne R. ^{[4
]}

Gamaldo, Charlene E. ^{[1
]}

Neubauer, David N. ^{[2
]}

Wang, Nae-Yuh ^{[5
,6
]}

Funderburk, Frank R. ^{[7
]}

Allen, Richard P. ^{[1
]}

David, Paula M. ^{[1
]}

Cadet, Jean Lud ^{[8
]}

机构：

[1] Johns Hopkins Med Inst, Dept Neurol, Bayview Med Ctr, Baltimore, MD 21205 USA

[2] Johns Hopkins Med Inst, Dept Psychiat & Behav Sci, Bayview Med Ctr, Baltimore, MD 21205 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA

[4] Univ Maryland, Sleep Disorders Ctr, Baltimore, MD 21201 USA

[5] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[6] Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA

[7] InCompass Syst, Columbia, MD USA

[8] NIDA, Mol Neuropsychiat Branch, DHHS, NIH,Intramural Res Program, Baltimore, MD USA

来源：

SLEEP MEDICINE | 2010年 / 11卷 / 09期

关键词：

Sleep; Polysomnography; Periodic leg movements; Marijuana; Abstinence; Substance abuse; Withdrawal; CANNABIS WITHDRAWAL; SEX-DIFFERENCES; TOLERANCE; SEVERITY; HEALTH; TIME; AGE;

D O I：

10.1016/j.sleep.2010.02.013

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background: Abrupt discontinuation of heavy marijuana (MJ) use is associated with self-reports of sleep difficulty. Disturbed sleep is clinically important because MJ users experiencing sleep problems may relapse to MJ use to improve their sleep quality. Few studies have used polysomnography (PSG) to characterize changes in sleep architecture during abrupt abstinence from heavy MJ use. Methods: We recorded PSG measures on nights 1, 2, 7, 8, and 13 after abrupt MJ discontinuation in 18 heavy MJ users residing in an inpatient unit. Results: Across abstinence, Total Sleep Time (TST), Sleep Efficiency (SEff), and amount of REM sleep declined, while Wake after Sleep Onset (WASO) and Periodic Limb Movements (PLM) increased. Furthermore, quantity (joints/week) and duration (years) of MJ use were positively associated with more PLMs. Conclusion: The treatment of sleep disturbance is a potential target for the management of cannabis use disorders since poor sleep could contribute to treatment failure in heavy MJ users. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：882 / 889

页数：8

共 38 条

[1]

[Anonymous], 2007, NSDUH SER

[2]

[Anonymous], [No title captured]

[3]

Circadian rhythms, sleep, and the menstrual cycle [J].

Baker, Fiona C. ;

Driver, Helen S. .

SLEEP MEDICINE, 2007, 8 (06) :613-622

[4]

Sleep disturbance in heavy marijuana users [J].

Bolla, Karen I. ;

Lesage, Suzanne R. ;

Gamaldo, Charlene E. ;

Neubauer, David N. ;

Funderburk, Frank R. ;

Cadet, Jean Lud ;

David, Paula M. ;

Verdejo-Garcia, Antonio ;

Benbrook, Amy R. .

SLEEP, 2008, 31 (06) :901-908

[5]

Dose-related neurocognitive effects of marijuana use [J].

Bolla, KI ;

Brown, K ;

Eldreth, D ;

Tate, K ;

Cadet, JL .

NEUROLOGY, 2002, 59 (09) :1337-1343

[6]

Neural substrates of faulty decision-making in abstinent marijuana users [J].

Bolla, KI ;

Eldreth, DA ;

Matochik, JA ;

Cadet, JL .

NEUROIMAGE, 2005, 26 (02) :480-492

[7]

BONNET M, 1993, SLEEP, V16, P748

[8]

BONNET MH, 1992, SLEEP, V15, P526

[9]

Boselli M, 1998, SLEEP, V21, P351

[10]

The time course and significance of cannabis withdrawal [J].

Budney, AJ ;

Moore, BA ;

Vandrey, RG ;

Hughes, JR .

JOURNAL OF ABNORMAL PSYCHOLOGY, 2003, 112 (03) :393-402

← 1 2 3 4 →