Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders

被引：231

作者：

Qian, ZM ^{[1
]}

Wang, Q ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Peoples R China

来源：

BRAIN RESEARCH REVIEWS | 1998年 / 27卷 / 03期

关键词：

lactotransferrin receptor; melanotransferrin; ceruloplasmin; divalent cation transporter; brain iron accumulation; neurodegenerative disease;

D O I：

10.1016/S0165-0173(98)00012-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

New findings on the role of LfR (lactotransferrin receptor), MTf (melanotransferrin), CP (ceruloplasmin) and DCT1 (Divalent Cation Transporter) in brain iron transport, obtained during the past 3 years, are important advances in the fields of physiology and pathophysiology of brain iron metabolism. According to these findings, disruption in the expression of these proteins in the brain is probably one of the important causes of the altered brain iron metabolism in age-related neurodegenerative diseases, including Parkinson's Disease, Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis. Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：257 / 267

页数：11

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