Molecular approaches to diagnosing and managing infectious diseases: Practicality and costs

被引:50
作者
Pfaller, MA [1 ]
机构
[1] Univ Iowa, Coll Med, Dept Pathol, Div Med Microbiol, Iowa City, IA 52242 USA
关键词
D O I
10.3201/eid0702.010234
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
As molecular techniques for identifying and detecting microorganisms in the clinical microbiology laboratory have become routine, questions about the cost of these techniques and their contribution to patient care need to be addressed. Molecular diagnosis is most appropriate for infectious agents that are difficult to detect, identify, or test for susceptibility in a timely fashion with conventional methods.
引用
收藏
页码:312 / 318
页数:7
相关论文
共 23 条
[1]   Rapid diagnosis of bacteremia by universal amplification of 23S ribosomal DNA followed by hybridization to an oligonucleotide array [J].
Anthony, RM ;
Brown, TJ ;
French, GL .
JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (02) :781-788
[2]  
Arbeit R. D., 1999, MANUAL CLIN MICROBIO, P116
[3]   RECURRENT EPIDEMICS CAUSED BY A SINGLE STRAIN OF ERYTHROMYCIN-RESISTANT STAPHYLOCOCCUS-AUREUS - THE IMPORTANCE OF MOLECULAR EPIDEMIOLOGY [J].
BACK, NA ;
LINNEMANN, CC ;
PFALLER, MA ;
STANECK, JL ;
MORTHLAND, V .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (11) :1329-1333
[4]  
Bergeron MG, 1998, INFECT CONT HOSP EP, V19, P560
[5]   Genetic methods for assessing antimicrobial resistance [J].
Cockerill, FR .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (02) :199-212
[6]  
CORMICAN MG, 1996, CLIN DIAGNOSIS MANAG, P1390
[7]   GENOTYPIC APPROACH TO THE STUDY OF BACTERIAL-RESISTANCE TO ANTIBIOTICS [J].
COURVALIN, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (06) :1019-1023
[8]   Pitfalls in establishing a molecular diagnostic laboratory [J].
FerreiraGonzalez, A ;
Garrett, CT .
HUMAN PATHOLOGY, 1996, 27 (05) :437-440
[9]   Sequence-based identification of microbial pathogens: A reconsideration of Koch's postulates [J].
Fredricks, DN ;
Relman, DA .
CLINICAL MICROBIOLOGY REVIEWS, 1996, 9 (01) :18-+
[10]  
Fredricks DN, 1999, CLIN INFECT DIS, V29, P475, DOI 10.1086/598618