Hydralysin, a novel animal group-selective paralytic and cytolytic protein from a noncnidocystic origin in hydra

被引：38

作者：

Zhang, ML

Fishman, Y

Sher, D

Zlotkin, E ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Cell & Anim Biol, IL-91904 Jerusalem, Israel

[2] Israeli Maritime Coll, IL-40297 Michmoret, Israel

来源：

BIOCHEMISTRY | 2003年 / 42卷 / 30期

关键词：

D O I：

10.1021/bi0343929

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Cnidaria, the production of neurotoxic polypeptides is attributed to the ectodermal stinging cells (cnidocytes), which are discharged for offensive (prey capture) and/or defensive purposes. In this study, a new paralysis-inducing (neurotoxic) protein from the green hydra Chlorohydra viridissima was purified, cloned, and expressed. This paralytic protein is unique in that it (1) is derived from a noncnidocysfic origin, (2) reveals a clear animal group-selective toxicity, (3) possesses an uncommon primary structure, remindful of pore-forming toxins, and (4) has a fast cytotoxic effect on insect cells but not on the tested mammalian cells. The possible biological role of such a noncnidocystic toxin is discussed.

引用

页码：8939 / 8944

页数：6

共 43 条

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