Non-covalent control of site-selective incorporation of the pyridoxal phosphate cofactor into a folded polypeptide motif-mimicking a key step in enzymatic transamination

被引：7

作者：

Allert, M ^{[1
]}

Kjellstrand, M ^{[1
]}

Broo, K ^{[1
]}

Nilsson, Å ^{[1
]}

Baltzer, L ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Chem, S-41296 Gothenburg, Sweden

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 15期

关键词：

D O I：

10.1039/a801741g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The site-selective incorporation of the pyridoxal phosphate cofactor into a designed polypeptide motif has been achieved and shown to be controlled by the non-covalent interactions between the phosphate group of the cofactor and a single arginine residue on the surface of the folded polypeptide.

引用

页码：1547 / 1548

页数：2

共 14 条

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