Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. Radix:: potential role of bradykinin, histamine and opioid receptor-mediated pathways

被引：50

作者：

Kim, SJ ^{[1
]}

Zhang, CG ^{[1
]}

Lim, JT ^{[1
]}

机构：

[1] Kyung Hee Univ, Sch Dent, Inst Oral Biol, Dept Pharmacol, Seoul 130701, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2003年 / 88卷 / 01期

关键词：

Asartan sieboldii miq; anti-nociception; anti-inflammation; bradykinin; histamine; opioid;

D O I：

10.1016/S0378-8741(03)00181-8

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The radix of Asarum sieboldii Miq. (AR) has been used to treat pain and inflammation in Korea. The present study was conducted to gain insights into the mechanism of actions regarding anti-nociceptive and anti-inflammatory activities of AR. Administration of methanol extract of AR caused dramatic anti-nociceptive effects based on acetic acid writhing and tail-flick assay. When naloxone (Nx) was pre-treated, AR extract failed to exert such anti-nociceptive effect in the tail-flick assays. These results suggest that AR extract have opioid-like activity. It also exerted significant anti-inflammatory effects in the rat paw edema assay. AR extract caused inhibition in the bradykinin (BK)/histamine-mediated ileum contractions of guinea pig. Taken together, these results provide evidence that the methanol extract of AR exerts anti-nociceptive and anti-inflammatory effects by activating opioid receptor as well as by inhibiting bradykinin and histamine-mediated actions. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：5 / 9

页数：5

共 16 条

[1] Multiple controls in inflammation - Extracellular and intracellular phospholipase A(2), inducible and constitutive cyclooxygenase, and inducible nitric oxide synthase [J].

Cirino, G .

BIOCHEMICAL PHARMACOLOGY, 1998, 55 (02) :105-111

[2]

D'amour FE, 1941, J PHARMACOL EXP THER, V72, P74

[3]

DEWEY WL, 1970, J PHARMACOL EXP THER, V175, P435

[4]

FUKAWA K, 1980, J PHARMACOL METHOD, V4, P251

[5]

Gao XP, 1996, J IMMUNOL, V157, P4624

[6]

GOLDSTEIN A, 1989, MOL PHARMACOL, V36, P265

[7] Improvement of C-reactive protein levels and body temperature of an elderly patient infected with Pseudomonas aeruginosa on treatment with Mao-Bushi-Saishin-To [J].

Kamei, T ;

Kondoh, T ;

Nagura, S ;

Toriumi, Y ;

Kumano, H ;

Tomioka, H .

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2000, 6 (03) :235-239

[8] Asiasari radix inhibits immunoglobulin E production on experimental models in vitro and in vivo [J].

Kim, HM ;

Moon, YS .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 1999, 21 (03) :469-481

[9]

LIU YQ, 1994, J PHARMACOL EXP THER, V268, P959

[10]

Lukacs NW, 1996, J IMMUNOL, V156, P3945

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